Specialized Research

Aviptadil

Also known as: RLF-100, VIP sintético, Peptídeo Intestinal Vasoativo sintético

Molecular Identifiers

Molecular Formula

C147H237N43O43S

CAS Number

40077-57-4

PubChem CID

16132300

Molecular Weight

3326.8 Da

Overview

Synthetic analog of vasoactive intestinal peptide (VIP), composed of 28 amino acids. Originally developed for respiratory and vascular conditions, it acts as a potent pulmonary vasodilator and anti-inflammatory agent. Extensively researched for lung protection and surfactant function regulation.

Sequence (1 letter): HSDAVFTDNYTRLRKQMAVKKYLNSILN

Extended notation: His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn

Half-life

~1-2 minutes (IV)

Administration Route

Intravenous or subcutaneous

Mechanism of Action

Agonism of VIP VPAC1 and VPAC2 receptors
Pulmonary and systemic vasodilation via cAMP increase
Anti-inflammatory action in pulmonary alveoli with reduction of pro-inflammatory cytokines
Stimulation of surfactant production by type II pneumocytes
Inhibition of apoptosis in alveolar epithelial cells
Modulation of the innate immune response in the lungs

Dosage Protocol

Data compiled from the literature. This does not constitute medical advice.

Parameter	Value
Dose	50-150 mcg per administration (IV or subcutaneous)
Frequency	1-3 times daily per protocol
Timing	Per clinical guidance
Duration	4-8 weeks

Reported Side Effects

Adverse effects described in the literature. Severity and frequency vary between individuals.

Hypotension
Tachycardia
Nausea
Diarrhea
Facial flushing

Product Properties

Purity	>98%
Appearance	White lyophilized powder
Solubility	Soluble in water, sterile saline, and bacteriostatic water
Source	Solid-phase peptide synthesis (SPPS)
Storage	Lyophilized: -20°C for up to 2 years, 2-8°C for up to 6 months. Reconstituted: 2-8°C, use within 24 hours. Protect from light and moisture. Short half-life — use reconstituted solution promptly.