An open label clinical trial of a peptide treatment serum and supporting regimen designed to improve the appearance of aging facial skin

This open-label clinical trial, conducted by dermatologist Zoe Diana Draelos, evaluated the efficacy of a topical serum containing acetyl octapeptide-3 (SNAP-8) and a supporting regimen in 29 women with visible signs of facial aging. The protocol consisted of 14 weeks of daily application, with standardized clinical assessments and photographic documentation at regular intervals.

Results demonstrated statistically significant improvement in the appearance of facial lines and periorbital wrinkles assessed at rest. Participants showed visible reduction in wrinkle depth, with progressive improvement throughout the treatment period. Expert evaluation confirmed the findings observed in standardized photographs.

• Overall skin texture also showed noticeable improvement
• The tolerability profile was excellent, with no significant adverse events
• Participants reported satisfaction with results in subjective assessments

The study is relevant for providing clinical evidence for SNAP-8, a peptide that acts by inhibiting SNARE complex formation, reducing facial muscle contraction in a manner analogous to (but gentler than) botulinum toxin. The findings support the use of cosmetic peptides as a non-invasive alternative for the treatment of expression wrinkles.