SNAP-8
Also known as: Acetyl Octapeptide-3, INYIM
Molecular Identifiers
Overview
Acetylated octapeptide with anti-wrinkle action. Modulates the SNARE complex to reduce facial muscle contraction, diminishing expression lines. Enhanced version of Argireline with two additional amino acids for greater efficacy.
EEMQRRAD Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp Half-life
~2-3 hours
Administration Route
Topical or subcutaneous
Category
Cosmetic & Skin
Mechanism of Action
- SNARE complex modulation (SNAP-25 protein)
- Reduction of neurotransmitter release at the neuromuscular junction
- Decrease of involuntary facial muscle contraction
- Attenuation of dynamic expression lines
- Botulinum toxin-like action in a non-invasive manner
Dosage Protocol
Data compiled from the literature. This does not constitute medical advice.
| Parameter | Value |
|---|---|
| Dose | Topical 3-10% or 100-500 mcg subcutaneous |
| Frequency | Topical 2x daily, subcutaneous 2-3x per week |
| Timing | Morning and evening (topical) |
| Duration | Continuous use (topical), 8-12 weeks (subcutaneous) |
Reported Side Effects
Adverse effects described in the literature. Severity and frequency vary between individuals.
- Mild skin irritation
- Redness
- Local sensitivity
Presentations & Preparation
Vials of SNAP-8 found in the research market:
Reconstitution
- Diluent: Bacteriostatic water
- Volume: 2 ml per 5 mg vial
- Slowly inject the diluent against the vial wall
- Gently swirl until fully dissolved
- Never shake
Storage
- Lyophilized: Refrigerated 2-8°C
- Reconstituted: Refrigerated 2-8°C (up to 30 days)
- Protect from direct light
- Do not freeze after reconstitution
Scientific Studies
Published studies on SNAP-8.
An open label clinical trial of a peptide treatment serum and supporting regimen designed to improve the appearance of aging facial skin
Draelos ZD, Kononov T, Fox T
Molecular modeling elucidates the cellular mechanism of synaptotagmin-SNARE inhibition: a novel plausible route to anti-wrinkle activity of botox-like cosmetic active molecules
Bhogale D, Bhagwat P, Bhojwani H
Related Peptides
Acetyl Octapeptide-1
Topical 3-5% · Twice daily
AHK-Cu
Topical or 200-500 mcg subcutaneous · 1-2 times daily (topical), every other day (subcutaneous)
Argireline
Topical 5-10% or 100-250 mcg subcutaneous · Topical twice daily, subcutaneous 2-3x per week
Decapeptide-12
Topical application · 1-2 times daily
GHK Basic
Topical or 200-600 mcg subcutaneous · 1-2 times daily (topical), every other day (subcutaneous)
Matrixyl
Topical application · 1-2 times daily