Cosmetic & Skin

Matrixyl

Also known as: Palmitoyl Pentapeptide-4, Pal-KTTKS

Molecular Identifiers

Molecular Formula

C39H75N7O10S

CAS Number

214047-00-4

PubChem CID

9897237

Molecular Weight

802.05 Da

Overview

Lipophilic pentapeptide (palmitoyl-KTTKS) that stimulates the synthesis of collagen types I, III, and IV, fibronectin, and hyaluronic acid in the dermis. Procollagen fragment with a palmitoyl group for skin penetration.

Sequence (1 letter): KTTKS
Extended notation: Lys-Thr-Thr-Lys-Ser

Half-life

Variable (topical use)

Administration Route

Topical

Category

Cosmetic & Skin

Mechanism of Action

  • Stimulation of collagen I, III, and IV synthesis
  • Increased fibronectin production
  • Promotion of hyaluronic acid synthesis
  • Signaling via the KTTKS matrikine sequence
  • Palmitoyl group facilitates dermal penetration

Dosage Protocol

Data compiled from the literature. This does not constitute medical advice.

Parameter Value
Dose Topical application
Frequency 1-2 times daily
Timing Morning and/or evening after cleansing
Duration Continuous use

Reported Side Effects

Adverse effects described in the literature. Severity and frequency vary between individuals.

  • Mild skin irritation (rare)
  • Transient redness

Presentations & Preparation

Vials of Matrixyl found in the research market:

100 mg (pó)50 ml (solução)

Reconstitution

  • Diluent: N/A (topical use)
  • Volume: N/A
  • Supplied as solution or incorporated in cosmetic formulations
  • Typical concentration 100-300 ppm

Storage

  • Lyophilized: Room temperature
  • Reconstituted: N/A
  • Protect from direct light
  • Keep container tightly closed
Reconstitution Calculator

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