Matrixyl
Also known as: Palmitoyl Pentapeptide-4, Pal-KTTKS
Molecular Identifiers
Overview
Lipophilic pentapeptide (palmitoyl-KTTKS) that stimulates the synthesis of collagen types I, III, and IV, fibronectin, and hyaluronic acid in the dermis. Procollagen fragment with a palmitoyl group for skin penetration.
KTTKS Lys-Thr-Thr-Lys-Ser Half-life
Variable (topical use)
Administration Route
Topical
Category
Cosmetic & Skin
Mechanism of Action
- Stimulation of collagen I, III, and IV synthesis
- Increased fibronectin production
- Promotion of hyaluronic acid synthesis
- Signaling via the KTTKS matrikine sequence
- Palmitoyl group facilitates dermal penetration
Dosage Protocol
Data compiled from the literature. This does not constitute medical advice.
| Parameter | Value |
|---|---|
| Dose | Topical application |
| Frequency | 1-2 times daily |
| Timing | Morning and/or evening after cleansing |
| Duration | Continuous use |
Reported Side Effects
Adverse effects described in the literature. Severity and frequency vary between individuals.
- Mild skin irritation (rare)
- Transient redness
Product Properties
| Purity | >98% |
| Appearance | White to off-white lyophilized powder or clear solution |
| Solubility | Soluble in water. For optimal solubility, DMSO or propylene glycol may be used as co-solvent due to the palmitoyl lipid chain. |
| Source | Solid-phase peptide synthesis (SPPS) with N-terminal palmitoylation |
| Storage | Lyophilized: -20°C for up to 2 years, 2-8°C for up to 6 months. Solution: 2-8°C for up to 6 months. Protect from light and moisture. Avoid repeated freeze-thaw cycles. |
Presentations & Preparation
Vials of Matrixyl found in the research market:
Reconstitution
- Diluent: N/A (topical use)
- Volume: N/A
- Supplied as solution or incorporated in cosmetic formulations
- Typical concentration 100-300 ppm
Storage
- Lyophilized: Room temperature
- Reconstituted: N/A
- Protect from direct light
- Keep container tightly closed
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