Argireline
Also known as: Acetyl Hexapeptide-8, Acetil Hexapeptídeo-8
Molecular Identifiers
Overview
Acetylated hexapeptide with anti-wrinkle action that inhibits the SNARE complex, reducing facial muscle contraction. Known as a non-invasive alternative to botulinum toxin for the treatment of expression lines.
EEMQRR Glu-Glu-Met-Gln-Arg-Arg Half-life
~2-3 hours
Administration Route
Topical or subcutaneous
Category
Cosmetic & Skin
Mechanism of Action
- Inhibition of the SNARE complex at the neuromuscular junction
- Competition with endogenous SNAP-25 protein
- Facial muscle relaxation
- Reduction of wrinkle and expression line depth
- Prevention of new expression line formation
Dosage Protocol
Data compiled from the literature. This does not constitute medical advice.
| Parameter | Value |
|---|---|
| Dose | Topical 5-10% or 100-250 mcg subcutaneous |
| Frequency | Topical twice daily, subcutaneous 2-3x per week |
| Timing | Morning and evening (topical) |
| Duration | Continuous use (topical), 8-12 weeks (subcutaneous) |
Reported Side Effects
Adverse effects described in the literature. Severity and frequency vary between individuals.
- Mild skin irritation
- Redness
- Local sensitivity
Presentations & Preparation
Vials of Argireline found in the research market:
Reconstitution
- Diluent: Bacteriostatic water
- Volume: 2 ml per 5 mg vial
- Inject the diluent slowly against the vial wall
- Gently swirl until fully dissolved
- Never shake
Storage
- Lyophilized: Refrigerated 2-8°C
- Reconstituted: Refrigerated 2-8°C (up to 30 days)
- Protect from direct light
- Do not freeze after reconstitution
Scientific Studies
Published studies on Argireline.
A synthetic hexapeptide (Argireline) with antiwrinkle activity
Blanes-Mira C, Clemente J, Jodas G, Gil A, Fernández-Ballester G, Ponsati B, Gutierrez L, Pérez-Payá E, Ferrer-Montiel A
The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study
Wang Y, Wang M, Xiao S, Pan P, Li P, Huo J
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