Cosmetic & Skin

Decapeptide-12

Also known as: Lumixyl Peptide

Molecular Identifiers

Molecular Formula

C65H90N18O17

CAS Number

137665-91-9

PubChem CID

25087629

Molecular Weight

~1.4 kDa

Overview

10-amino acid peptide developed as a topical depigmenting agent. Competitively inhibits the tyrosinase enzyme, reducing melanin production without cytotoxicity to melanocytes.

Sequence (1 letter): YRSRKYSSWY
Extended notation: Tyr-Arg-Ser-Arg-Lys-Tyr-Ser-Ser-Trp-Tyr

Half-life

Variable (topical use)

Administration Route

Topical

Category

Cosmetic & Skin

Mechanism of Action

  • Competitive tyrosinase inhibition
  • Reduction of melanin synthesis
  • No cytotoxicity to melanocytes
  • Gradual and uniform skin lightening
  • Reversible mechanism (no permanent depigmentation)

Dosage Protocol

Data compiled from the literature. This does not constitute medical advice.

Parameter Value
Dose Topical application
Frequency 1-2 times daily
Timing Morning and/or evening
Duration 8-12 weeks for visible results

Reported Side Effects

Adverse effects described in the literature. Severity and frequency vary between individuals.

  • Mild skin irritation (rare)

Product Properties

Purity >98%
Appearance White lyophilized powder
Solubility Soluble in water and bacteriostatic water
Source Solid-phase peptide synthesis (SPPS)
Storage Lyophilized: -20°C for up to 2 years, 2-8°C for up to 6 months. Reconstituted: 2-8°C for up to 4 weeks. Protect from light and moisture. Avoid repeated freeze-thaw cycles.

Presentations & Preparation

Vials of Decapeptide-12 found in the research market:

100 mg200 mg

Reconstitution

  • Diluent: N/A (topical use)
  • Volume: N/A
  • Supplied as powder or topical formulations
  • Typical concentration 100-200 ppm

Storage

  • Lyophilized: Room temperature
  • Reconstituted: N/A
  • Protect from light and moisture
  • Keep tightly sealed
Reconstitution Calculator

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