GHK Basic
Also known as: GHK, Gly-His-Lys
Molecular Identifiers
Overview
Copper-binding tripeptide in its base form (without complexed copper). Naturally present in human plasma, colostrum, and saliva. Promotes collagen synthesis, wound healing, and tissue remodeling. Precursor to GHK-Cu.
GHK Gly-His-Lys Half-life
~2-4 hours
Administration Route
Topical or subcutaneous
Category
Cosmetic & Skin
Mechanism of Action
- Stimulation of type I and III collagen synthesis
- Promotion of wound healing and tissue repair
- Anti-inflammatory activity via cytokine modulation
- Extracellular matrix remodeling
- Attraction of mesenchymal stem cells to the repair site
Dosage Protocol
Data compiled from the literature. This does not constitute medical advice.
| Parameter | Value |
|---|---|
| Dose | Topical or 200-600 mcg subcutaneous |
| Frequency | 1-2 times daily (topical), every other day (subcutaneous) |
| Timing | Preferably at night |
| Duration | 4-12 weeks |
Reported Side Effects
Adverse effects described in the literature. Severity and frequency vary between individuals.
- Mild skin irritation
- Local redness
Product Properties
| Purity | >98% |
| Appearance | White lyophilized powder |
| Solubility | Soluble in water and bacteriostatic water |
| Source | Solid-phase peptide synthesis (SPPS) |
| Storage | Lyophilized: -20°C for up to 2 years, 2-8°C for up to 6 months. Reconstituted: 2-8°C for up to 4 weeks. Protect from light and moisture. Avoid repeated freeze-thaw cycles. |
Presentations & Preparation
Vials of GHK Basic found in the research market:
Reconstitution
- Diluent: Bacteriostatic water
- Volume: 2 ml per vial
- Slowly inject the diluent along the vial wall
- Gently swirl until fully dissolved
- Never shake
Storage
- Lyophilized: Refrigerated 2-8°C
- Reconstituted: Refrigerated 2-8°C (up to 30 days)
- Protect from direct light
- Do not freeze after reconstitution
Scientific Studies
Published studies on GHK Basic.
Related Peptides
Acetyl Octapeptide-1
Topical 3-5% · Twice daily
AHK-Cu
Topical or 200-500 mcg subcutaneous · 1-2 times daily (topical), every other day (subcutaneous)
Argireline
Topical 5-10% or 100-250 mcg subcutaneous · Topical twice daily, subcutaneous 2-3x per week
Decapeptide-12
Topical application · 1-2 times daily
Matrixyl
Topical application · 1-2 times daily
Melanotan I
0.5-1 mg per injection · Every other day (loading phase), weekly (maintenance)