Geroprotective effect of thymalin and epithalamin

This long-term clinical study, conducted by Russian researchers Vladimir Khavinson and Vyacheslav Morozov from the St. Petersburg Institute of Bioregulation and Gerontology, evaluated the geroprotective effects of Thymalin (thymic peptide) and epithalamin (pineal peptide) in 266 elderly patients followed for 6 to 8 years.

Participants received periodic cycles of treatment with the peptide bioregulators, being assessed for comprehensive clinical parameters throughout the follow-up period. The results demonstrated significant improvements in multiple organ systems: cardiovascular (normalization of blood pressure and cardiac function), endocrine (improvement in hormonal markers), immune (recovery of lymphocyte subpopulations), and nervous (cognitive improvement).

• Mortality in the Thymalin-treated group was 2.0-2.1 times lower than in the control group
• The combination of Thymalin + epithalamin produced even more pronounced synergistic effects
• There was a reduction in the incidence of acute respiratory and infectious diseases
• Quality of life and functional capacity improved significantly

This study is one of the most cited evidence on the geroprotective potential of peptide bioregulators, although it should be interpreted in the context of Russian gerontological research, which sometimes uses methodologies distinct from Western standards. The findings suggest that peptide modulation of the thymus may have real impact on longevity and quality of life in elderly populations.