Specialized Research Khavinson Bioregulator

Thymalin

Also known as: Timulina, Thymulin

Molecular Identifiers

Molecular Formula

C33H54N12O15

CAS Number

63958-90-7

PubChem CID

3085284

Molecular Weight

858.86 Da

Overview

Thymic bioregulatory peptide with a molecular weight of approximately 858.86 Da. Originally isolated from the thymus, it acts on T lymphocyte maturation and immune system regulation. Developed within the Russian peptide bioregulation school, it is used in short cycles to restore immune function and support thymus activity.

Thymalin is studied as a thymic bioregulator, promoting T lymphocyte maturation, modulating the balance between helper and suppressor T cell subpopulations, and stimulating NK cell activity. Clinical interest lies in immunosenescence, post-infectious immune support, and restoration of thymic function in populations with marked thymic involution. It requires zinc as a cofactor for full biological activity.

Outside Russia and some Eastern European countries, Thymalin has no broad regulatory approval. It is used in short cyclic protocols (5 to 10 days, repeated 2 to 4 times per year) prescribed through compounding pharmacies as off-label use, generally via the intramuscular or subcutaneous route. It was developed within the Russian peptide bioregulation school, and most of the available clinical literature is of Russian origin.

Within the Khavinson family, Thymalin is the "ancestral" representative of the thymus/immunity axis, from which shorter peptides derive: Vilon, the Lys-Glu dipeptide, is the minimalist expression of the same immunoregulatory logic, and Crystagen, the Glu-Asp-Pro tripeptide, is presented as a thymic cytogen aimed at thymus-independent immunity. All of this comparative literature is largely Russian and preclinical.

Thymic nonapeptide with known sequence: pGlu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn. Requires zinc as a cofactor for biological activity.

Half-life

~3-5 hours

Administration Route

Subcutaneous or intramuscular

Mechanism of Action

Promotion of T lymphocyte maturation and differentiation
Regulation and restoration of immune system function
Support for thymus function and regeneration
Modulation of the balance between helper and suppressor T lymphocytes
Stimulation of natural killer (NK) cell activity

Dosage Protocol

Data compiled from the literature. This does not constitute medical advice.

Parameter	Value
Dose	5-20 mg per intramuscular injection
Frequency	Once daily
Timing	Morning
Duration	5-10 days, cycled 2-4 times per year

Reported Side Effects

Adverse effects described in the literature. Severity and frequency vary between individuals.

Injection site pain
Allergic reaction (rare)
Mild transient fever

Product Properties

Purity	Varies (complex mixture)
Appearance	White to off-white lyophilized powder
Solubility	Soluble in water and bacteriostatic water
Source	Extraction from bovine thymus
Storage	Lyophilized: -20°C for up to 2 years, 2-8°C for up to 6 months. Reconstituted: 2-8°C for up to 4 weeks. Protect from light and moisture. Avoid repeated freeze-thaw cycles.