Dermorphin
Also known as: Dermorfina, Dermorpin
Molecular Identifiers
Overview
Natural opioid heptapeptide isolated from the skin of Phyllomedusa frogs, with a molecular weight of approximately 803.88 Da. Contains the non-standard amino acid D-alanine at position 2, conferring exceptional potency and selectivity for the mu-opioid receptor. Considered one of the most potent known peptide analgesics, with 30-40 times greater activity than morphine.
Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH₂ Contains D-alanine at position 2
Half-life
~2-4 hours
Administration Route
Subcutaneous
Category
Specialized Research
Mechanism of Action
- Potent and selective mu-opioid receptor (MOR) agonism
- Deep analgesia via inhibition of nociceptive transmission
- Modulation of the descending pain control pathway
- Inhibition of substance P release in sensory neurons
- Central and peripheral action on opioid receptors
Dosage Protocol
Data compiled from the literature. This does not constitute medical advice.
| Parameter | Value |
|---|---|
| Dose | 1-5 mcg/kg (research only) |
| Frequency | Single dose or per research protocol |
| Timing | Acute administration under supervision |
| Duration | Acute use only (not indicated for prolonged use) |
Reported Side Effects
Adverse effects described in the literature. Severity and frequency vary between individuals.
- Respiratory depression
- Sedation
- Nausea
- Rapid tolerance
- Dependence (potential)
Presentations & Preparation
Vials of Dermorphin found in the research market:
Reconstitution
- Diluent: Sterile saline solution
- Volume: 1 ml per vial
- Reconstitute with sterile saline solution
- Gently swirl until fully dissolved — never shake
- Prepare only in a controlled research environment
Storage
- Lyophilized: Refrigerated 2-8°C
- Reconstituted: Use immediately after reconstitution
- Protect from direct light
- Discard unused solution
- Long-term storage at -20°C
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