Glutationa
Also known as: GSH, Glutathione, L-Glutationa
Molecular Identifiers
Overview
Antioxidant tripeptide (glutamic acid-cysteine-glycine) with an unconventional gamma bond, present in virtually all cells of the body. With a molecular weight of 307.32 Da, it is considered the primary intracellular antioxidant of the human body. Essential for hepatic detoxification, mitochondrial protection, and immune system support.
γ-Glu-Cys-Gly Tripeptide with γ-glutamyl bond (unconventional)
Half-life
~10-15 minutes (IV)
Administration Route
Intravenous, subcutaneous, or oral
Category
Specialized Research
Mechanism of Action
- Master antioxidant — neutralization of reactive oxygen species (ROS)
- Hepatic detoxification via conjugation with xenobiotics (phase II)
- Immune function support and lymphocyte proliferation
- Mitochondrial function protection and optimization
- Regeneration of other antioxidants such as vitamins C and E
Dosage Protocol
Data compiled from the literature. This does not constitute medical advice.
| Parameter | Value |
|---|---|
| Dose | 200-600 mg IV or 100-500 mg subcutaneous |
| Frequency | 1-3 times per week |
| Timing | Morning or as directed |
| Duration | Continuous or 4-12 week cycles |
Reported Side Effects
Adverse effects described in the literature. Severity and frequency vary between individuals.
- Abdominal cramps (oral)
- Transient flushing (IV)
- Mild headache
Presentations & Preparation
Vials of Glutationa found in the research market:
Reconstitution
- Diluent: Bacteriostatic water
- Volume: 2-5 ml per vial (depending on concentration)
- Slowly inject the diluent against the vial wall
- Gently swirl until fully dissolved
- Never shake
Storage
- Lyophilized: Refrigerated 2-8°C
- Reconstituted: Refrigerated 2-8°C (use within 24-48 hours)
- Protect from direct light
- Glutathione oxidizes rapidly after reconstitution
- Do not freeze after reconstitution
Scientific Studies
Published studies on Glutationa.
Randomized controlled trial of oral glutathione supplementation on body stores of glutathione
Richie JP Jr, Nichenametla S, Neidig W, Calcagnotto A, Haley JS, Schell TD, Muscat JE
Randomized Clinical Trial of How Long-Term Glutathione Supplementation Offers Protection from Oxidative Damage and Improves HbA1c in Elderly Type 2 Diabetic Patients
Kalamkar S, Acharya J, Kolappurath Madathil A, Gajjar V, Divate U, Karandikar-Iyer S, Goel P, Ghaskadbi S
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