N-Acetyl Epithalon
Also known as: N-Acetyl Epitalon, N-Acetyl Epithalone, Ac-AEDG, N-Acetyl Epithalon Amidate
Molecular Identifiers
Overview
Modified version of Epithalon with N-acetylation that confers greater enzymatic stability and bioavailability. Retains the same mechanisms of action as the original Epithalon (telomerase activation, pineal gland support) with extended half-life and potential for oral administration.
The main interest around N-Acetyl Epithalon is to replicate the researched effects of the original Epithalon (telomerase activation, pineal gland support, and circadian regulation) with superior pharmacokinetics. N-terminal acetylation protects against aminopeptidases, extending the estimated half-life to 4-6 hours and enabling the Amidate version for oral/sublingual administration.
It has no regulatory approval from any agency (FDA, EMA, ANVISA) and its use is restricted to the research market. Usage patterns follow classical Epithalon — short 10-20 day cycles, repeated 2-4 times per year, typically at night to align with melatonin. Most evidence is still preclinical and originates from the group of Russian researcher Vladimir Khavinson, with few randomized clinical trials.
Within the Khavinson family, N-Acetyl Epithalon is the acetylated variant of the classical Epithalon (the Ala-Glu-Asp-Gly tetrapeptide): it keeps the same sequence and the same proposed axis of action (pineal, telomeres, anti-aging), distinguished by greater enzymatic stability and oral bioavailability — while the original Epithalon requires injection, and Pinealon (the Glu-Asp-Arg tripeptide) sits in the same subgroup with a more brain/pineal profile. All of this comparative literature is largely Russian and preclinical.
AEDG Ac-Ala-Glu-Asp-Gly N-acetylated form of the tetrapeptide Epithalon (Ala-Glu-Asp-Gly). N-terminal acetylation protects against degradation by aminopeptidases. The Amidate variant includes additional C-terminal amidation.
Half-life
~4-6 hours (estimated, longer than native Epithalon ~2-3 hours)
Administration Route
Subcutaneous, intramuscular, or oral/sublingual (Amidate version)
Category
Specialized Research
Mechanism of Action
- Telomerase activation and telomere maintenance
- Support for pineal gland function and melatonin production
- Circadian rhythm regulation and cortisol normalization
- Antioxidant properties
- Stimulation of gene expression during neurogenesis via epigenetic mechanism (histone binding)
- Greater enzymatic stability than native Epithalon due to N-acetylation
Dosage Protocol
Data compiled from the literature. This does not constitute medical advice.
| Parameter | Value |
|---|---|
| Dose | 1-5 mg per subcutaneous injection (or equivalent oral dose in the Amidate version) |
| Frequency | Once daily or every other day |
| Timing | Preferably at night (aligned with the melatonin cycle) |
| Duration | 10-20 days, cycled 2-4 times per year |
Reported Side Effects
Adverse effects described in the literature. Severity and frequency vary between individuals.
- Injection site pain (rare)
- Mild headache (rare)
- Safety profile similar to native Epithalon
Product Properties
| Purity | >98% |
| Appearance | White lyophilized powder |
| Solubility | Soluble in water and bacteriostatic water |
| Source | Solid-phase peptide synthesis (SPPS) |
| Storage | Lyophilized: -20°C for up to 2 years, 2-8°C for up to 6 months. Reconstituted: 2-8°C for up to 4 weeks. Protect from light and moisture. Avoid repeated freeze-thaw cycles. |
Presentations & Preparation
Vials of N-Acetyl Epithalon found in the research market:
Reconstitution
- Diluent: Bacteriostatic water
- Volume: 2 ml per vial
- Inject the diluent slowly against the vial wall
- Gently swirl until fully dissolved
- Never shake
- Amidate version also available for oral/sublingual use
Storage
- Lyophilized: -20°C or refrigerated 2-8°C
- Reconstituted: Refrigerated 2-8°C (up to 30 days)
- Protect from direct light
- Do not freeze after reconstitution
- Superior stability compared to native Epithalon at room temperature
Scientific Studies
Published studies on N-Acetyl Epithalon.
AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism
Khavinson VKh, Diomede F, Mironova E, Linkova N, Trofimova S, Trubiani O, Caputi S, Sinjari B
Synthetic tetrapeptide epitalon restores disturbed neuroendocrine regulation in senescent monkeys
Khavinson VKh, Goncharova ND, Lapin BA
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