Specialized Research Khavinson Bioregulator

N-Acetyl Epithalon

Also known as: N-Acetyl Epitalon, N-Acetyl Epithalone, Ac-AEDG, N-Acetyl Epithalon Amidate

Molecular Identifiers

Molecular Formula

C16H24N4O10

Molecular Weight

~432,39 Da

Overview

Modified version of Epithalon with N-acetylation that confers greater enzymatic stability and bioavailability. Retains the same mechanisms of action as the original Epithalon (telomerase activation, pineal gland support) with extended half-life and potential for oral administration.

Sequence (1 letter): AEDG
Extended notation: Ac-Ala-Glu-Asp-Gly

N-acetylated form of the tetrapeptide Epithalon (Ala-Glu-Asp-Gly). N-terminal acetylation protects against degradation by aminopeptidases. The Amidate variant includes additional C-terminal amidation.

Half-life

~4-6 hours (estimated, longer than native Epithalon ~2-3 hours)

Administration Route

Subcutaneous, intramuscular, or oral/sublingual (Amidate version)

Category

Specialized Research

Mechanism of Action

  • Telomerase activation and telomere maintenance
  • Support for pineal gland function and melatonin production
  • Circadian rhythm regulation and cortisol normalization
  • Antioxidant properties
  • Stimulation of gene expression during neurogenesis via epigenetic mechanism (histone binding)
  • Greater enzymatic stability than native Epithalon due to N-acetylation

Dosage Protocol

Data compiled from the literature. This does not constitute medical advice.

Parameter Value
Dose 5-10 mg per injection (or oral in the Amidate version)
Frequency Once daily or every other day
Timing Preferably at night (aligned with the melatonin cycle)
Duration 10-20 days, cycled 2-4 times per year

Reported Side Effects

Adverse effects described in the literature. Severity and frequency vary between individuals.

  • Injection site pain (rare)
  • Mild headache (rare)
  • Safety profile similar to native Epithalon

Presentations & Preparation

Vials of N-Acetyl Epithalon found in the research market:

5 mg10 mg15 mg20 mg

Reconstitution

  • Diluent: Bacteriostatic water
  • Volume: 2 ml per vial
  • Inject the diluent slowly against the vial wall
  • Gently swirl until fully dissolved
  • Never shake
  • Amidate version also available for oral/sublingual use

Storage

  • Lyophilized: -20°C or refrigerated 2-8°C
  • Reconstituted: Refrigerated 2-8°C (up to 30 days)
  • Protect from direct light
  • Do not freeze after reconstitution
  • Superior stability compared to native Epithalon at room temperature
Reconstitution Calculator

Scientific Studies

Published studies on N-Acetyl Epithalon.

2001 · Neuroendocrinol Lett

Synthetic tetrapeptide epitalon restores disturbed neuroendocrine regulation in senescent monkeys

Khavinson VKh, Goncharova ND, Lapin BA
2020 · Molecules

AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism

Khavinson VKh, Diomede F, Mironova E, Linkova N, Trofimova S, Trubiani O, Caputi S, Sinjari B

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