NAD+
Also known as: Nicotinamide Adenine Dinucleotide
Molecular Identifiers
Overview
Essential coenzyme for cellular energy metabolism. Declines with age. Supplementation aims to restore cellular levels to support DNA repair and mitochondrial function.
Small molecule — dinucleotide coenzyme (nicotinamide adenine dinucleotide), not a peptide
Half-life
~30 minutes (IV)
Administration Route
Intravenous or subcutaneous
Category
Specialized Research
Mechanism of Action
- Essential cofactor for sirtuins (SIRT1-7)
- Substrate for PARP (DNA repair)
- Support for the mitochondrial electron transport chain
- Circadian clock regulation
Dosage Protocol
Data compiled from the literature. This does not constitute medical advice.
| Parameter | Value |
|---|---|
| Dose | 50-250 mg per injection |
| Frequency | 2-3 times per week |
| Timing | Preferably morning |
| Duration | Continuous as tolerated |
Reported Side Effects
Adverse effects described in the literature. Severity and frequency vary between individuals.
- Flushing
- Nausea
- Cramps
- Chest discomfort (rapid infusion)
- Headache
Presentations & Preparation
Vials of NAD+ found in the research market:
Reconstitution
- Diluent: Bacteriostatic water
- Volume: According to concentration
- Inject the diluent slowly
- Gently swirl until fully dissolved
- May cause flushing — start with a low dose
Storage
- Lyophilized: -20°C or refrigerated 2-8°C
- Reconstituted: Refrigerated 2-8°C (up to 14 days)
- Limited stability after reconstitution
- Protect from direct light
Scientific Studies
Published studies on NAD+.
Related Peptides
Aviptadil
50-150 mcg per administration (IV or subcutaneous) · 1-3 times daily per protocol
B7-33
100-500 mcg per injection (subcutaneous) · Once daily
Bronchogen
5-10 mg per day via subcutaneous injection · Once daily
Cardiogen
5-10 mg per day subcutaneously · Once daily
Chonluten
5-10 mg per day subcutaneously · Once daily
Crystagen
5-10 mg per day via subcutaneous injection · Once daily