Specialized Research

VIP

Also known as: Peptídeo Intestinal Vasoativo

Molecular Identifiers

Molecular Formula

C147H237N43O43S

PubChem CID

53314964

Molecular Weight

3326.82 Da

Overview

28-amino acid neuropeptide with a molecular weight of approximately 3,326.82 Da. Naturally produced in the central and peripheral nervous systems, gastrointestinal tract, and pancreas. Has broad vasodilatory, anti-inflammatory, immunomodulatory, and neuroprotective actions across multiple organ systems.

Sequence (1 letter): HSDAVFTDNYTRLRKQMAVKKYLNSILN
Extended notation: His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn

Half-life

~1-2 minutes

Administration Route

Intranasal or subcutaneous

Category

Specialized Research

Mechanism of Action

  • Potent vasodilation via VPAC1 and VPAC2 receptors
  • Systemic anti-inflammatory action and cytokine regulation
  • Immune system modulation and promotion of immune tolerance
  • Neuroprotection and nervous system function support
  • Regulation of gastrointestinal motility and pancreatic secretion

Dosage Protocol

Data compiled from the literature. This does not constitute medical advice.

Parameter Value
Dose 50-200 mcg per administration
Frequency 1-2 times daily
Timing Morning and/or evening
Duration 4-8 weeks

Reported Side Effects

Adverse effects described in the literature. Severity and frequency vary between individuals.

  • Hypotension
  • Tachycardia
  • Facial flushing
  • Nausea
  • Diarrhea

Presentations & Preparation

Vials of VIP found in the research market:

5 mg10 mg15 mg20 mg

Reconstitution

  • Diluent: Bacteriostatic water
  • Volume: 2 ml per 5 mg vial
  • Slowly inject the diluent against the vial wall
  • Gently swirl until fully dissolved
  • Never shake

Storage

  • Lyophilized: Refrigerated 2-8°C
  • Reconstituted: Refrigerated 2-8°C (up to 14 days)
  • Protect from direct light
  • Do not freeze after reconstitution
  • VIP is sensitive to degradation — use soon after reconstitution
Reconstitution Calculator

Scientific Studies

Published studies on VIP.

2003 · J Clin Invest

Vasoactive intestinal peptide as a new drug for treatment of primary pulmonary hypertension

Petkov V, Mosgoeller W, Ziesche R, Raderer M, Stiebellehner L, Vonbank K, Funk GC, Hamilton G, Novotny C, Burian B, Block LH
2010 · Am J Respir Crit Care Med

Inhaled vasoactive intestinal peptide exerts immunoregulatory effects in sarcoidosis

Prasse A, Zissel G, Lützen N, Schupp J, Schmiedlin R, Gonzalez-Rey E, et al.

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