Metabolic & Fat Loss

Adipotide

Also known as: FTPP, Prohibitin-Targeting Peptide

Molecular Identifiers

Molecular Formula

C111H206N36O28S2

PubChem CID

163360068

Overview

Synthetic peptide that combines a vascular targeting sequence with a pro-apoptotic domain (FTPP). Designed to selectively target the white adipose tissue vasculature, inducing apoptosis in endothelial cells supplying fatty tissue.

Conjugated peptide — vascular homing sequence (CKGGRAKDC) fused with pro-apoptotic sequence (KLAKLAK)₂

Half-life

~30 minutes

Administration Route

Subcutaneous

Category

Metabolic & Fat Loss

Mechanism of Action

  • Binding to prohibitin on the vascular endothelial surface of adipose tissue
  • Internalization and release of the pro-apoptotic domain D(KLAKLAK)2
  • Induction of apoptosis in endothelial cells of adipose vessels
  • Disruption of blood supply to white adipose tissue
  • Reabsorption of fatty tissue through vascular deprivation

Dosage Protocol

Data compiled from the literature. This does not constitute medical advice.

Parameter Value
Dose 0.5-1 mg/kg per injection (subcutaneous)
Frequency Once daily
Timing Morning, fasted
Duration 4-8 weeks

Reported Side Effects

Adverse effects described in the literature. Severity and frequency vary between individuals.

  • Dehydration
  • Fatigue
  • Transient proteinuria
  • Injection site pain

Presentations & Preparation

Vials of Adipotide found in the research market:

2 mg5 mg10 mg15 mg20 mg

Reconstitution

  • Diluent: Bacteriostatic water
  • Volume: 1-2 ml per vial
  • Slowly inject the diluent along the vial wall
  • Gently swirl until fully dissolved — never shake
  • Calculate dose based on body weight

Storage

  • Lyophilized: Refrigerated 2-8°C
  • Reconstituted: Refrigerated 2-8°C (up to 14 days)
  • Protect from direct light
  • Do not freeze after reconstitution
  • Limited stability after reconstitution
Reconstitution Calculator

Scientific Studies

Published studies on Adipotide.

2011 · Sci Transl Med

A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys

Barnhart KF, Christianson DR, Hanley PW, Driessen WHP, Bernacky BJ, Baze WB, Wen S, Tian M, et al.

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