Metabolic & Fat Loss

AICAR

Also known as: Acadesine, AICA Riboside

Molecular Identifiers

Molecular Formula

C9H14N4O5

CAS Number

2627-69-2

PubChem CID

17513

Molecular Weight

258.23 Da

Overview

AMPK activator with exercise mimetic properties. Improves endurance and fat oxidation. Adenosine analog that directly activates AMPK kinase.

Small molecule — nucleoside analog (AICA ribonucleoside), not a peptide

Half-life

~2-3 hours

Administration Route

Subcutaneous

Category

Metabolic & Fat Loss

Mechanism of Action

  • Direct activation of AMPK kinase
  • Exercise mimetic
  • Improvement of endurance capacity
  • Increase in fatty acid oxidation
  • Improvement of muscle glucose uptake

Dosage Protocol

Data compiled from the literature. This does not constitute medical advice.

Parameter Value
Dose 50-150 mg per injection
Frequency 2-3 times per week
Timing Pre-workout
Duration 8-12 weeks

Reported Side Effects

Adverse effects described in the literature. Severity and frequency vary between individuals.

  • Hypoglycemia
  • Fatigue
  • Gastrointestinal discomfort
  • Lactic acidosis (high doses)

Product Properties

Purity >99%
Appearance White to off-white crystalline powder
Solubility Soluble in water and DMSO
Source Chemical synthesis
Storage Desiccated at -20°C for up to 3 years. At 2-8°C for up to 12 months. Reconstituted: -20°C for up to 1 month. Hygroscopic — protect from moisture.

Presentations & Preparation

Vials of AICAR found in the research market:

50 mg100 mg500 mg

Reconstitution

  • Diluent: Bacteriostatic water
  • Volume: According to vial concentration
  • Slowly inject the diluent along the vial wall
  • Gently swirl until fully dissolved
  • High doses may require a larger volume of diluent

Storage

  • Lyophilized: -20°C or refrigerated 2-8°C
  • Reconstituted: Refrigerated 2-8°C (up to 30 days)
  • Protect from direct light
  • Do not freeze after reconstitution
Reconstitution Calculator

Scientific Studies

Published studies on AICAR.

2008 · Cell

AMPK and PPARdelta agonists are exercise mimetics

Narkar VA, Downes M, Yu RT, Embler E, Wang YX, Banayo E, Mihaylova MM, Nelson MC, Zou Y, Juguilon H, Kang H, Shaw RJ, Evans RM

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