Argipressin
Also known as: AVP, Vasopressina, ADH
Molecular Identifiers
Overview
Cyclic antidiuretic hormone (ADH) with a disulfide bridge. Produced in the hypothalamus and released by the neurohypophysis. Regulates water reabsorption in the kidneys, vasoconstriction, and body fluid homeostasis.
CYFQNCPRG Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly Half-life
~10-20 minutes
Administration Route
Intravenous or subcutaneous
Category
Hormonal Regulation
Mechanism of Action
- V1a receptor agonism (vasoconstriction)
- V2 receptor agonism (water reabsorption in renal collecting ducts)
- V1b receptor agonism (ACTH release from the pituitary)
- Aquaporin-2 insertion into the apical membrane of collecting ducts
- Regulation of plasma osmolality and blood volume
Dosage Protocol
Data compiled from the literature. This does not constitute medical advice.
| Parameter | Value |
|---|---|
| Dose | 5-20 IU or 1-4 mcg/kg |
| Frequency | As clinically needed |
| Timing | Per protocol |
| Duration | As needed |
Reported Side Effects
Adverse effects described in the literature. Severity and frequency vary between individuals.
- Nausea
- Abdominal cramps
- Pallor
- Transient hypertension
- Bradycardia
Presentations & Preparation
Vials of Argipressin found in the research market:
Reconstitution
- Diluent: Bacteriostatic water
- Volume: 1 ml per vial
- Inject the diluent slowly against the vial wall
- Gently swirl until fully dissolved
- Never shake
Storage
- Lyophilized: Refrigerated 2-8°C
- Reconstituted: Refrigerated 2-8°C (use within 24 hours)
- Protect from direct light
- Sensitive to degradation - use promptly after reconstitution
Related Peptides
Cetrorelix
0.25-3 mg per injection · Once daily (0.25 mg) or single dose (3 mg)
Gonadorelin
100-200 mcg per injection · 2-3 times per week
HCG
250-500 IU per injection · 2-3 times per week
Kisspeptin-10
1-10 mcg per injection · Per research protocol
α-MSH
0.5-2 mg per injection · Once daily or every other day
Oxytocin
10-40 IU intranasal or 50-200 mcg subcutaneous · 1-2 times daily