Hormonal Regulation

Kisspeptin-10

Also known as: Kisspeptina-10

Molecular Identifiers

Molecular Formula

C63H83N17O14

PubChem CID

25240297

Overview

Upstream regulator of GnRH. Research in reproductive endocrinology. Highly variable dosage per study protocol.

Sequence (1 letter): YNWNSFGLRF
Extended notation: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe

Half-life

~4-5 minutes

Administration Route

Subcutaneous or intravenous

Category

Hormonal Regulation

Mechanism of Action

  • Stimulation of GnRH release via GPR54 receptor
  • Upstream regulation of the reproductive axis
  • Modulation of pulsatile LH secretion

Dosage Protocol

Data compiled from the literature. This does not constitute medical advice.

Parameter Value
Dose 1-10 mcg per injection
Frequency Per research protocol
Timing Per study design
Duration Per study

Reported Side Effects

Adverse effects described in the literature. Severity and frequency vary between individuals.

  • Facial flushing
  • Headache
  • Nausea
  • Injection site pain

Presentations & Preparation

Vials of Kisspeptin-10 found in the research market:

5 mg10 mg15 mg20 mg

Reconstitution

  • Diluent: Bacteriostatic water
  • Volume: 1 ml per vial
  • Inject the diluent slowly against the vial wall
  • Gently swirl until fully dissolved
  • Never shake

Storage

  • Lyophilized: -20°C
  • Reconstituted: Refrigerated 2-8°C (use promptly)
  • Protect from direct light
  • Limited stability after reconstitution
Reconstitution Calculator

Scientific Studies

Published studies on Kisspeptin-10.

2011 · J Clin Endocrinol Metab

Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men

George JT, Veldhuis JD, Roseweir AK, Newton CL, Faccenda E, Millar RP, Anderson RA
2013 · Clin Endocrinol (Oxf)

Exploring the pathophysiology of hypogonadism in men with type 2 diabetes: kisspeptin-10 stimulates serum testosterone and LH secretion

George JT, Millar RP, Anderson RA

Related Peptides

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