Gonadorelin
Also known as: GnRH
Molecular Identifiers
Overview
Gonadotropin-releasing hormone (GnRH). Stimulates LH and FSH release from the pituitary gland. Research on the HPG axis. Pulsatile administration may be beneficial.
FDA-approved as Factrel for diagnostic use of gonadotropic function and as Lutrepulse for therapeutic pulsatile administration in the treatment of hypogonadotropic hypogonadism and infertility.
QHWSYGLRPG Gln-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly Half-life
~2-4 minutes
Administration Route
Subcutaneous or intravenous
Category
Hormonal Regulation
Mechanism of Action
- Stimulation of LH and FSH release from the anterior pituitary
- Regulation of the hypothalamic-pituitary-gonadal (HPG) axis
- Pulsatile administration mimics endogenous secretion
Dosage Protocol
Data compiled from the literature. This does not constitute medical advice.
| Parameter | Value |
|---|---|
| Dose | 100-200 mcg per injection |
| Frequency | 2-3 times per week |
| Timing | Any time of day |
| Duration | As per research protocol |
Reported Side Effects
Adverse effects described in the literature. Severity and frequency vary between individuals.
- Headache
- Facial flushing
- Nausea
- Injection site pain
- Hot flashes
Presentations & Preparation
Vials of Gonadorelin found in the research market:
Reconstitution
- Diluent: Bacteriostatic water
- Volume: 2 ml per vial
- Slowly inject the diluent against the vial wall
- Gently swirl until fully dissolved
- Never shake
Storage
- Lyophilized: Refrigerated 2-8°C
- Reconstituted: Refrigerated 2-8°C (up to 30 days)
- Protect from direct light
- Do not freeze after reconstitution
Scientific Studies
Published studies on Gonadorelin.
Predictors of outcome of long-term GnRH therapy in men with idiopathic hypogonadotropic hypogonadism
Pitteloud N, Hayes FJ, Dwyer A, Boepple PA, Lee H, Crowley WF Jr
The pulsatile gonadorelin pump induces earlier spermatogenesis than cyclical gonadotropin therapy in congenital hypogonadotropic hypogonadism men
Zhang L, Cai K, Wang Y, Ji W, Cheng Z, Chen G, Liao Z
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