α-MSH
Also known as: Alfa-MSH, α-Melanotropina
Molecular Identifiers
Overview
Alpha melanocyte-stimulating hormone, an endogenous 13-amino acid peptide derived from pro-opiomelanocortin (POMC). Acts on multiple melanocortin receptors with functions in pigmentation, anti-inflammation, and immunomodulation.
SYSMEHFRWGKPV Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val Half-life
~20-30 minutes
Administration Route
Subcutaneous
Category
Hormonal Regulation
Mechanism of Action
- Agonism of MC1R to MC5R receptors (melanocortins)
- Stimulation of melanogenesis and melanin production
- Potent anti-inflammatory effect via NF-κB inhibition
- Immunomodulation and cytokine regulation
- Modulation of feeding behavior via MC4R
- Regulation of energy homeostasis
Dosage Protocol
Data compiled from the literature. This does not constitute medical advice.
| Parameter | Value |
|---|---|
| Dose | 0.5-2 mg per injection |
| Frequency | Once daily or every other day |
| Timing | Any time of day |
| Duration | 2-4 weeks |
Reported Side Effects
Adverse effects described in the literature. Severity and frequency vary between individuals.
- Nausea
- Facial flushing
- Hyperpigmentation
- Fatigue
Presentations & Preparation
Vials of α-MSH found in the research market:
Reconstitution
- Diluent: Bacteriostatic water
- Volume: 2 ml per vial
- Slowly inject the diluent against the vial wall
- Gently swirl until fully dissolved
- Never shake
Storage
- Lyophilized: Refrigerated 2-8°C
- Reconstituted: Refrigerated 2-8°C (up to 14 days)
- Protect from direct light
- Do not freeze after reconstitution
- Short half-life peptide - use promptly
Related Peptides
Argipressin
5-20 IU or 1-4 mcg/kg · As clinically needed
Cetrorelix
0.25-3 mg per injection · Once daily (0.25 mg) or single dose (3 mg)
Gonadorelin
100-200 mcg per injection · 2-3 times per week
HCG
250-500 IU per injection · 2-3 times per week
Kisspeptin-10
1-10 mcg per injection · Per research protocol
Oxytocin
10-40 IU intranasal or 50-200 mcg subcutaneous · 1-2 times daily