Metabolic & Fat Loss

IGF-1 LR3

Also known as: Long R3 IGF-1, Receptor Grade IGF-1

Molecular Identifiers

Molecular Formula

C400H625N111O115S9

CAS Number

946870-92-4

PubChem CID

168009904

Molecular Weight

~9.1 kDa

Overview

Long-acting analog of insulin-like growth factor type 1 (IGF-1). Modified with Arg→Glu substitution at position 3 and 13-amino acid N-terminal extension, resulting in reduced affinity for IGFBPs and significantly longer half-life.

Sequence (1 letter): MFPAMPLSSLFVNGPRTLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSA

Extended notation:

Met-Phe-Pro-Ala-Met-Pro-Leu-Ser-Ser-Leu-Phe-Val-Asn-Gly-Pro-Arg-Thr-Leu-Cys-Gly-Ala-Glu-Leu-Val-Asp-Ala-Leu-Gln-Phe-Val-Cys-Gly-Asp-Arg-Gly-Phe-Tyr-Phe-Asn-Lys-Pro-Thr-Gly-Tyr-Gly-Ser-Ser-Ser-Arg-Arg-Ala-Pro-Gln-Thr-Gly-Ile-Val-Asp-Glu-Cys-Cys-Phe-Arg-Ser-Cys-Asp-Leu-Arg-Arg-Leu-Glu-Met-Tyr-Cys-Ala-Pro-Leu-Lys-Pro-Ala-Lys-Ser-Ala

Modified IGF-1 analog with 83 amino acids. 13 aa N-terminal extension.

Half-life

~20-30 hours

Administration Route

Subcutaneous or intramuscular

Mechanism of Action

IGF-1R receptor activation with increased affinity
Promotion of protein synthesis and muscle hypertrophy
Anti-catabolic effect
Cell proliferation and differentiation
Prolonged half-life due to low affinity for IGFBPs

Dosage Protocol

Data compiled from the literature. This does not constitute medical advice.

Parameter	Value
Dose	20-50 mcg per injection
Frequency	Once daily (training days)
Timing	Immediately post-workout
Duration	4-6 weeks (with equal off intervals)

Reported Side Effects

Adverse effects described in the literature. Severity and frequency vary between individuals.

Hypoglycemia
Joint pain
Swelling
Headache
Numbness in extremities

Product Properties

Purity	>95%
Appearance	White lyophilized powder
Solubility	Soluble in water and bacteriostatic water. Acidic solutions (0.1M acetic acid) recommended for long-term stability.
Source	Recombinant DNA technology (E. coli)
Storage	Lyophilized: -20°C for up to 2 years, 2-8°C for up to 3 months. Reconstituted: 2-8°C for up to 2 weeks. Keep frozen for long-term storage. Protect from light and moisture. Avoid repeated freeze-thaw cycles.