GH Secretagogues

GHRP-2

Also known as: Pralmorelin

Molecular Identifiers

Molecular Formula

C45H55N9O6

PubChem CID

6918245

Overview

Second-generation GH-releasing peptide with moderate ghrelin activity. Strong GH release with moderate appetite increase. Potent when combined with GHRH analogs.

Extended notation: D-Ala-D-βNal-Ala-Trp-D-Phe-Lys-NH₂

Contains D-amino acids (D-Ala, D-βNal, D-Phe)

Half-life

~25-30 minutes

Administration Route

Subcutaneous

Category

GH Secretagogues

Mechanism of Action

  • GHS-R1a receptor agonist
  • Potent dose-dependent GH release
  • Moderate ghrelin activity (appetite increase)
  • Synergism with exogenous GHRH

Dosage Protocol

Data compiled from the literature. This does not constitute medical advice.

Parameter Value
Dose 100-300 mcg per injection
Frequency 2-3 times per day
Timing Morning, post-workout and before bedtime
Duration 8-12 weeks

Reported Side Effects

Adverse effects described in the literature. Severity and frequency vary between individuals.

  • Increased appetite
  • Water retention
  • Tingling
  • Elevated cortisol/prolactin

Presentations & Preparation

Vials of GHRP-2 found in the research market:

5 mg10 mg

Reconstitution

  • Diluent: Bacteriostatic water
  • Volume: 2 ml per 5 mg vial
  • Inject the diluent slowly against the vial wall
  • Gently swirl until fully dissolved
  • Never shake

Storage

  • Lyophilized: Room temperature or refrigerated
  • Reconstituted: Refrigerated 2-8°C (up to 30 days)
  • Protect from direct light
  • Do not freeze after reconstitution
Reconstitution Calculator

Scientific Studies

Published studies on GHRP-2.

1997 · J Endocrinol

Treatment effects of intranasal growth hormone releasing peptide-2 in children with short stature

Pihoker C, Badger TM, Reynolds GA, Bowers CY
2004 · J Clin Endocrinol Metab

Sustained elevation of pulsatile growth hormone (GH) secretion and insulin-like growth factor I (IGF-I), IGF-binding protein-3 (IGFBP-3), and IGFBP-5 concentrations during 30-day continuous subcutaneous infusion of GH-releasing peptide-2 in older men and women

Bowers CY, Granda R, Mohan S, Kuipers J, Baylink D, Veldhuis JD
2005 · J Clin Endocrinol Metab

Growth hormone releasing peptide-2 (GHRP-2), like ghrelin, increases food intake in healthy men

Laferrere B, Abraham C, Russell CD, Bowers CY

Related Peptides

CJC-1295 with DAC

1-2 mg per week · Once per week

CJC-1295 sem DAC

100-200 mcg per injection · 2-3 times daily

GHRP-6

100-300 mcg per injection · 2-3 times per day

Hexarelin

200-300 mcg per injection · 2-3 times per day

Ipamorelin

200-300 mcg per injection · 2-3 times daily

MK-677

10-25 mg per dose · Once daily