Ipamorelin
Molecular Identifiers
Overview
Third-generation GH secretagogue with a highly selective profile. Synthetic pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2) that acts as a selective agonist of the ghrelin receptor (GHS-R1a). Does not significantly elevate cortisol, prolactin, or ACTH.
Aib-His-D-2-Nal-D-Phe-Lys-NH₂ Contains D-amino acids and non-natural amino acids (Aib, D-2-Nal, D-Phe)
Half-life
~2 hours
Administration Route
Subcutaneous
Category
GH Secretagogues
Mechanism of Action
- Selective agonism of the GHS-R1a receptor (ghrelin receptor)
- Dose-dependent GH stimulation from the anterior pituitary
- Synergism with GHRH (CJC-1295/Mod GRF 1-29)
- No significant elevation of cortisol or prolactin
- Preserves the physiological pulsatile pattern of GH secretion
Dosage Protocol
Data compiled from the literature. This does not constitute medical advice.
| Parameter | Value |
|---|---|
| Dose | 200-300 mcg per injection |
| Frequency | 2-3 times daily |
| Timing | Morning, post-workout, and before bed |
| Duration | 8-12 weeks |
Reported Side Effects
Adverse effects described in the literature. Severity and frequency vary between individuals.
- Headache
- Mild nausea
- Facial flushing
- Tingling
Product Properties
| Purity | >99% |
| Appearance | White lyophilized powder |
| Solubility | Soluble in bacteriostatic water |
| Source | Solid-phase peptide synthesis (SPPS) |
| Storage | Short-term: <4°C; Long-term: -20°C to -80°C |
Presentations & Preparation
Vials of Ipamorelin found in the research market:
Reconstitution
- Diluent: Bacteriostatic water
- Volume: 2 ml per 5 mg vial
- Inject slowly against the vial wall
- Gently swirl until fully dissolved
- Never shake
Storage
- Lyophilized: Room temperature (up to 24 months)
- Reconstituted: Refrigerated 2-8°C (up to 4-6 weeks)
- Do not freeze after reconstitution
- Protect from direct light
Scientific Studies
Published studies on Ipamorelin.
Ipamorelin, the first selective growth hormone secretagogue
Raun K, Hansen BS, Johansen NL, Thøgersen H, Madsen K, Ankersen M, Andersen PH
Oral administration of ipamorelin, a peptidic growth hormone secretagogue, in adult beagles
Johansen PB, Nowak J, Skjaerbaek C, Flyvbjerg A, Andreassen TT, Wilken M, Orskov H
Related Peptides
CJC-1295 with DAC
1-2 mg per week · Once per week
CJC-1295 sem DAC
100-200 mcg per injection · 2-3 times daily
GHRP-2
100-300 mcg per injection · 2-3 times per day
GHRP-6
100-300 mcg per injection · 2-3 times per day
Hexarelin
200-300 mcg per injection · 2-3 times per day
MK-677
10-25 mg per dose · Once daily