GH Secretagogues

Sermorelin

Also known as: GRF 1-29

Molecular Identifiers

Molecular Formula

C149H246N44O42S

PubChem CID

16132413

Overview

GHRH analog with gentle GH stimulation. Suitable for long-term protocols. Good option for anti-aging research with a conservative profile.

Sequence (1 letter): YADAIFTNSYRKVLGQLSARKLLQDIMSR
Extended notation: Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg

Half-life

~10-20 minutes

Administration Route

Subcutaneous

Category

GH Secretagogues

Mechanism of Action

  • Native GHRH analog (fragment 1-29)
  • Physiological stimulation of GH secretion
  • Preserves natural negative feedback
  • Promotes REM sleep and recovery

Dosage Protocol

Data compiled from the literature. This does not constitute medical advice.

Parameter Value
Dose 200-500 mcg per injection
Frequency Once daily
Timing Before bedtime
Duration 12+ weeks

Reported Side Effects

Adverse effects described in the literature. Severity and frequency vary between individuals.

  • Facial flushing
  • Headache
  • Dizziness
  • Injection site pain
  • Drowsiness

Presentations & Preparation

Vials of Sermorelin found in the research market:

2 mg5 mg15 mg

Reconstitution

  • Diluent: Bacteriostatic water
  • Volume: 2 ml per 5 mg vial
  • Slowly inject the diluent against the vial wall
  • Gently swirl until fully dissolved
  • Never shake

Storage

  • Lyophilized: Refrigerated 2-8°C
  • Reconstituted: Refrigerated 2-8°C (up to 30 days)
  • Protect from direct light
  • Do not freeze after reconstitution
Reconstitution Calculator

Scientific Studies

Published studies on Sermorelin.

1997 · J Clin Endocrinol Metab

Endocrine and metabolic effects of long-term administration of [Nle27]growth hormone-releasing hormone-(1-29)-NH2 in age-advanced men and women

Khorram O, Laughlin GA, Yen SS
2006 · Clin Interv Aging

Sermorelin: A better approach to management of adult-onset growth hormone insufficiency?

Walker RF

Related Peptides

CJC-1295 with DAC

1-2 mg per week · Once per week

CJC-1295 sem DAC

100-200 mcg per injection · 2-3 times daily

GHRP-2

100-300 mcg per injection · 2-3 times per day

GHRP-6

100-300 mcg per injection · 2-3 times per day

Hexarelin

200-300 mcg per injection · 2-3 times per day

Ipamorelin

200-300 mcg per injection · 2-3 times daily