Hormonal Regulation FDA Approved

Triptorelin

Also known as: Triptorrelina

Molecular Identifiers

Molecular Formula

C64H82N18O13

PubChem CID

25074470

Overview

Long-acting GnRH agonist. Used in specific hormonal protocols. A single dose can have a prolonged effect lasting weeks.

Approved by the FDA as Trelstar for the treatment of advanced prostate cancer and as Decapeptyl for central precocious puberty. GnRH agonist with extended- release formulations of 1, 3, and 6 months.

Extended notation: pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH₂

Contains D-tryptophan at position 6

Half-life

~6-8 hours

Administration Route

Intramuscular or subcutaneous

Category

Hormonal Regulation

Mechanism of Action

  • Potent GnRH receptor agonist
  • Initial stimulation followed by receptor desensitization
  • Long-lasting effect (3-4 weeks)

Dosage Protocol

Data compiled from the literature. This does not constitute medical advice.

Parameter Value
Dose 100 mcg per injection
Frequency Once every 3-4 weeks
Timing Any time of day
Duration According to protocol

Reported Side Effects

Adverse effects described in the literature. Severity and frequency vary between individuals.

  • Hot flashes
  • Decreased libido
  • Bone pain (initial flare)
  • Injection site reactions
  • Fatigue

Presentations & Preparation

Vials of Triptorelin found in the research market:

100 mcg2 mg

Reconstitution

  • Diluent: Bacteriostatic water
  • Volume: 1 ml per vial
  • Inject the diluent slowly against the vial wall
  • Gently swirl until completely dissolved
  • Never shake

Storage

  • Lyophilized: Refrigerated 2-8°C
  • Reconstituted: Refrigerated 2-8°C (use immediately)
  • Protect from direct light
  • Use promptly after reconstitution
Reconstitution Calculator

Scientific Studies

Published studies on Triptorelin.

2010 · Fertil Steril

Anabolic steroids purchased on the Internet as a cause of prolonged hypogonadotropic hypogonadism

Menon DK
2017 · Adv Ther

Efficacy of testosterone suppression with sustained-release triptorelin in advanced prostate cancer

Breul J, Lundstrom E, Purcea D, Venetz WP, Cabri P, Dutailly P, Goldfischer E

Related Peptides

Argipressin

5-20 IU or 1-4 mcg/kg · As clinically needed

Cetrorelix

0.25-3 mg per injection · Once daily (0.25 mg) or single dose (3 mg)

Gonadorelin

100-200 mcg per injection · 2-3 times per week

HCG

250-500 IU per injection · 2-3 times per week

Kisspeptin-10

1-10 mcg per injection · Per research protocol

α-MSH

0.5-2 mg per injection · Once daily or every other day