Healing & Recovery

ARA-290

Also known as: Cibinetide

Molecular Identifiers

Molecular Formula

C51H84N16O21

CAS Number

1208243-50-8

PubChem CID

91810664

Molecular Weight

1257.4 Da

Overview

Synthetic 11-amino acid peptide derived from erythropoietin (EPO), designed to selectively activate the innate repair receptor (IRR) without erythropoietic effects. With a molecular weight of approximately 1,257.4 Da, it possesses neuroprotective, anti-inflammatory, and tissue repair properties without stimulating red blood cell production.

Sequence (1 letter): QEQLERALNSS
Extended notation: pGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser

First residue is pyroglutamic acid (pGlu), not glutamine

Half-life

~2-3 minutes (IV), longer SC

Administration Route

Subcutaneous

Category

Healing & Recovery

Mechanism of Action

  • Selective activation of the innate repair receptor (IRR/EPOR-βcR)
  • Neuroprotection and peripheral nerve fiber repair
  • Anti-inflammatory action via suppression of pro-inflammatory cytokines
  • Promotion of tissue repair and cellular regeneration
  • Modulation of the innate immune response

Dosage Protocol

Data compiled from the literature. This does not constitute medical advice.

Parameter Value
Dose 2-4 mg per injection
Frequency Once daily
Timing Morning or as directed
Duration 4-12 weeks

Reported Side Effects

Adverse effects described in the literature. Severity and frequency vary between individuals.

  • Headache
  • Mild nausea
  • Dizziness
  • Injection site pain

Product Properties

Purity >98%
Appearance White lyophilized powder
Solubility Soluble in water and bacteriostatic water
Source Solid-phase peptide synthesis (SPPS)
Storage Lyophilized: -20°C for up to 2 years, 2-8°C for up to 6 months. Reconstituted: 2-8°C for up to 4 weeks. Protect from light and moisture. Avoid repeated freeze-thaw cycles.

Presentations & Preparation

Vials of ARA-290 found in the research market:

5 mg10 mg15 mg20 mg30 mg

Reconstitution

  • Diluent: Bacteriostatic water
  • Volume: 2 ml per vial
  • Inject the diluent slowly against the vial wall
  • Gently swirl until fully dissolved
  • Never shake

Storage

  • Lyophilized: Refrigerated 2-8°C
  • Reconstituted: Refrigerated 2-8°C (up to 30 days)
  • Protect from direct light
  • Do not freeze after reconstitution
Reconstitution Calculator

Scientific Studies

Published studies on ARA-290.

2012 · Mol Med

Safety and efficacy of ARA 290 in sarcoidosis patients with symptoms of small fiber neuropathy: a randomized, double-blind pilot study

Heij L, Niesters M, Swartjes M, Hoitsma E, Drent M, Dunne A, Grutters JC, Vogels O, Brines M, Cerami A, Dahan A
2015 · Mol Med

ARA 290, a nonerythropoietic peptide engineered from erythropoietin, improves metabolic control and neuropathic symptoms in patients with type 2 diabetes

Brines M, Dunne AN, van Velzen M, Proto PL, Ostenson CG, Kirk RI, Petropoulos IN, Javed S, Malik RA, Cerami A, Dahan A

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