Healing & Recovery

GHK-Cu

Also known as: Copper Peptide, Peptídeo de Cobre

Molecular Identifiers

Molecular Formula

C14H24N6O4

CAS Number

49557-75-7

PubChem CID

73587

Overview

Copper tripeptide (Gly-His-Lys-Cu²⁺) with collagen synthesis, wound healing, and anti-inflammatory properties. Naturally present in human plasma with levels that decline with age.

Sequence (1 letter): GHK
Extended notation: Gly-His-Lys

Half-life

~2-4 hours

Administration Route

Topical or subcutaneous

Category

Healing & Recovery

Mechanism of Action

  • Promotion of type I and III collagen synthesis
  • Stimulation of fibroblast proliferation
  • Anti-inflammatory effect via cytokine modulation
  • Attraction of immune cells for tissue repair
  • Promotion of angiogenesis and nerve regeneration

Dosage Protocol

Data compiled from the literature. This does not constitute medical advice.

Parameter Value
Dose 1-3 mg per injection
Frequency Once daily or every other day
Timing Preferably at night
Duration 8-12 weeks

Reported Side Effects

Adverse effects described in the literature. Severity and frequency vary between individuals.

  • Mild skin irritation
  • Local redness
  • Transient pigmentation

Product Properties

Purity >98%
Appearance Bluish lyophilized powder
Solubility Soluble in water
Source Chemical synthesis
Storage Refrigerated 2-8°C; protect from light

Presentations & Preparation

Vials of GHK-Cu found in the research market:

15 mg20 mg50 mg75 mg100 mg

Reconstitution

  • Diluent: Bacteriostatic water
  • Volume: 2 ml per vial
  • Slowly inject the diluent along the vial wall
  • Gently swirl until fully dissolved
  • Solution should have a slight bluish tint

Storage

  • Lyophilized: Refrigerated 2-8°C
  • Reconstituted: Refrigerated 2-8°C (up to 30 days)
  • Protect from direct light
  • Do not freeze after reconstitution
Reconstitution Calculator

Scientific Studies

Published studies on GHK-Cu.

2012 · Int J Mol Sci

Regenerative and protective actions of the GHK-Cu peptide in the light of the new gene data

Pickart L, Vasquez-Soltero JM, Margolina A
2012 · Oxid Med Cell Longev

The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging

Pickart L, Margolina A

Related Peptides

ARA-290

2-4 mg per injection · Once daily

BPC-157

250-500 mcg per injection · 1-2 times daily

Cartalax

5-10 mg per day · Once daily

LL-37

50-200 mcg per injection · Once daily

MGF

200-400 mcg per injection · Once daily (MGF) or 2-3 times per week (PEG-MGF)

TB-500

2-5 mg per injection · Twice per week