Healing & Recovery

TB-500

Also known as: Thymosin Beta-4, Tβ4

Molecular Identifiers

Molecular Formula

C36H66N10O13

CAS Number

476014-70-7

PubChem CID

10169788

Overview

Synthetic fragment of Thymosin Beta-4, a 43-amino acid protein present in virtually all nucleated cells. Acts on G-actin sequestration, promoting cell migration, differentiation, and new blood vessel formation.

Sequence (1 letter): LKKTETQ
Extended notation: Leu-Lys-Lys-Thr-Glu-Thr-Gln

Half-life

~2-3 hours

Administration Route

Subcutaneous or intramuscular

Category

Healing & Recovery

Mechanism of Action

  • Sequestration of monomeric G-actin, regulating the cytoskeleton
  • Promotion of angiogenesis via VEGF upregulation
  • Reduction of inflammation through cytokine modulation
  • Promotion of cell migration (keratinocytes, endothelial cells)
  • Stem cell differentiation at injury sites

Dosage Protocol

Data compiled from the literature. This does not constitute medical advice.

Parameter Value
Dose 2-5 mg per injection
Frequency Twice per week
Timing Any time of day
Duration 4-8 weeks

Reported Side Effects

Adverse effects described in the literature. Severity and frequency vary between individuals.

  • Mild headache
  • Lethargy
  • Flushing at injection site
  • Nausea (rare)

Product Properties

Purity >99%
Appearance White lyophilized powder
Solubility Soluble in water
Source Solid-phase peptide synthesis (SPPS)
Storage Short-term: <4°C; Long-term: -20°C to -80°C

Presentations & Preparation

Vials of TB-500 found in the research market:

2 mg5 mg10 mg

Reconstitution

  • Diluent: Bacteriostatic water
  • Volume: 1-2 ml per 5 mg vial
  • Slowly inject along the vial wall
  • Wait for complete dissolution without shaking
  • Gently swirl if necessary

Storage

  • Lyophilized: Room temperature or refrigerated
  • Reconstituted: Refrigerated 2-8°C (up to 3-4 weeks)
  • Do not refreeze after reconstitution
  • Protect from light and excessive heat
Reconstitution Calculator

Scientific Studies

Published studies on TB-500.

1999 · J Invest Dermatol

Thymosin β4 promotes dermal healing

Malinda KM, Sidhu GS, Mani H, et al.
2007 · Nature

Thymosin beta4 promotes blood vessel formation and stem cell migration

Smart N, Risebro CA, Melville AA, et al.

Related Peptides

ARA-290

2-4 mg per injection · Once daily

BPC-157

250-500 mcg per injection · 1-2 times daily

Cartalax

5-10 mg per day · Once daily

GHK-Cu

1-3 mg per injection · Once daily or every other day

LL-37

50-200 mcg per injection · Once daily

MGF

200-400 mcg per injection · Once daily (MGF) or 2-3 times per week (PEG-MGF)