Cortagen
Also known as: Peptídeo cortical
Molecular Identifiers
Overview
Cerebral cortex bioregulatory tetrapeptide developed by the Khavinson group. Regulates cortical function and modulates gene expression in the central nervous system. Used in short cycles for cognitive function support and neuroprotection.
AEDP Ala-Glu-Asp-Pro Half-life
~2-4 hours
Administration Route
Subcutaneous or intramuscular
Category
Cognitive & Neuroprotective
Mechanism of Action
- Regulation of cerebral cortex function
- Modulation of gene expression in the central nervous system
- Neuroprotection and support for neuronal integrity
- Normalization of cerebral bioelectrical activity
- Bioregulatory effect on cortical tissues
Dosage Protocol
Data compiled from the literature. This does not constitute medical advice.
| Parameter | Value |
|---|---|
| Dose | 5-10 mg per day via subcutaneous injection |
| Frequency | Once daily |
| Timing | Morning or as per protocol |
| Duration | 10-20 days, cycled periodically |
Reported Side Effects
Adverse effects described in the literature. Severity and frequency vary between individuals.
- Injection site pain
- Local redness (rare)
Product Properties
| Purity | >95% |
| Appearance | White lyophilized powder |
| Solubility | Soluble in water and bacteriostatic water |
| Source | Solid-phase peptide synthesis (SPPS) |
| Storage | Lyophilized: -20°C for up to 2 years, 2-8°C for up to 6 months. Reconstituted: 2-8°C for up to 4 weeks. Protect from light and moisture. Avoid repeated freeze-thaw cycles. |
Presentations & Preparation
Vials of Cortagen found in the research market:
Reconstitution
- Diluent: Bacteriostatic water
- Volume: 2 ml per vial
- Inject the diluent slowly against the vial wall
- Gently swirl until fully dissolved
- Never shake
Storage
- Lyophilized: Refrigerated 2-8°C
- Reconstituted: Refrigerated 2-8°C (up to 30 days)
- Protect from direct light
- Do not freeze after reconstitution
Scientific Studies
Published studies on Cortagen.
Effect of Tetrapeptide Cortagen on Regeneration of Sciatic Nerve
Turchaninova LN, Kolosova LI, Malinin VV, Moiseeva AB, Nozdrachev AD, Khavinson VK
Elucidation of the Effect of Brain Cortex Tetrapeptide Cortagen on Gene Expression in Mouse Heart by Microarray
Anisimov SV, Khavinson VK, Anisimov VN
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