Cognitive & Neuroprotective

Dihexa

Also known as: PNB-0408

Molecular Identifiers

Molecular Formula

C27H44N4O5

CAS Number

1401708-83-5

PubChem CID

125355097

Molecular Weight

504.67 Da

Overview

Potent cognitive enhancer, angiotensin IV analog. Activates the HGF/c-Met pathway, promoting synaptogenesis and neurotrophism. Considered up to 10 million times more potent than BDNF in forming new synaptic connections in preclinical studies.

Extended notation: N-Hexanoyl-Tyr-Ile-(6)-aminohexanoic amide

Peptidomimetic — modified angiotensin IV derivative with hexanoyl and aminohexanoic chains

Half-life

~12 hours

Administration Route

Subcutaneous or oral

Mechanism of Action

Activation of the HGF/c-Met pathway (hepatocyte growth factor)
Promotion of synaptogenesis and new neural connection formation
Potent neurotrophic effect
Prevention of HGF degradation by the heparanase enzyme
Improvement of synaptic plasticity and spatial memory

Dosage Protocol

Data compiled from the literature. This does not constitute medical advice.

Parameter	Value
Dose	10-20 mg per subcutaneous injection or oral (research)
Frequency	Once daily
Timing	Morning or early afternoon
Duration	4-8 weeks

Reported Side Effects

Adverse effects described in the literature. Severity and frequency vary between individuals.

Headache
Anxiety
Insomnia
Increased blood pressure (rare)

Product Properties

Purity	>98%
Appearance	White lyophilized powder
Solubility	Soluble in water and bacteriostatic water
Source	Solid-phase peptide synthesis (SPPS)
Storage	Lyophilized: -20°C for up to 2 years, 2-8°C for up to 6 months. Reconstituted: 2-8°C for up to 4 weeks. Protect from light and moisture. Avoid repeated freeze-thaw cycles.