Dihexa
Also known as: PNB-0408
Molecular Identifiers
Overview
Potent cognitive enhancer, angiotensin IV analog. Activates the HGF/c-Met pathway, promoting synaptogenesis and neurotrophism. Considered up to 10 million times more potent than BDNF in forming new synaptic connections in preclinical studies.
Small molecule — modified hexapeptide with unconventional structure derived from angiotensin IV
Half-life
~12 hours
Administration Route
Subcutaneous or oral
Category
Cognitive & Neuroprotective
Mechanism of Action
- Activation of the HGF/c-Met pathway (hepatocyte growth factor)
- Promotion of synaptogenesis and new neural connection formation
- Potent neurotrophic effect
- Prevention of HGF degradation by the heparanase enzyme
- Improvement of synaptic plasticity and spatial memory
Dosage Protocol
Data compiled from the literature. This does not constitute medical advice.
| Parameter | Value |
|---|---|
| Dose | 10-20 mg per subcutaneous injection or oral (research) |
| Frequency | Once daily |
| Timing | Morning or early afternoon |
| Duration | 4-8 weeks |
Reported Side Effects
Adverse effects described in the literature. Severity and frequency vary between individuals.
- Headache
- Anxiety
- Insomnia
- Increased blood pressure (rare)
Presentations & Preparation
Vials of Dihexa found in the research market:
Reconstitution
- Diluent: Bacteriostatic water
- Volume: 2 ml per vial
- Inject the diluent slowly against the vial wall
- Gently swirl until fully dissolved
- Never shake
- Also available in oral formulation for research
Storage
- Lyophilized: Refrigerated 2-8°C
- Reconstituted: Refrigerated 2-8°C (up to 30 days)
- Protect from direct light
- Do not freeze after reconstitution
Scientific Studies
Published studies on Dihexa.
The Procognitive and Synaptogenic Effects of Angiotensin IV-Derived Peptides Are Dependent on Activation of the Hepatocyte Growth Factor/c-Met System
Benoist CC, Kawas LH, Zhu M, Bhatt KA, Bhatt SJ, Bhatt JP, Wright JW, Harding JW
AngIV-Analog Dihexa Rescues Cognitive Impairment and Recovers Memory in the APP/PS1 Mouse via the PI3K/AKT Signaling Pathway
Sun X, Deng Y, Fu X, Wang S, Duan R, Zhang Y
Related Peptides
Adamax
100-500 mcg via intranasal or subcutaneous · 1-2 times daily
Cerebrolysin
5-30 ml per injection · Once daily
Cortagen
5-10 mg per day via subcutaneous injection · Once daily
DSIP
100-300 mcg per subcutaneous injection · Once daily
Epithalon
5-10 mg per injection · Once daily or every other day
FG Loop
5-10 mg per subcutaneous injection · Once daily or every other day