Cognitive & Neuroprotective

FG Loop

Also known as: FGL, NCAM peptide

Molecular Identifiers

Molecular Formula

C71H116N20O25

CAS Number

499993-62-3

PubChem CID

16200289

Overview

Peptide derived from neural cell adhesion molecule (NCAM). Activates FGFR receptors, promoting synaptic plasticity and neuroprotection. Researched for cognitive enhancement, neural recovery, and neurodegenerative diseases.

Sequence (1 letter): EVYVVAENQQGKSKA

Extended notation: Glu-Val-Tyr-Val-Val-Ala-Glu-Asn-Gln-Gln-Gly-Lys-Ser-Lys-Ala

Research peptide — sequence derived from the FG loop of neural cell adhesion molecule (NCAM)

Half-life

~1-3 hours

Administration Route

Subcutaneous

Mechanism of Action

Activation of FGFR receptors (fibroblast growth factor receptor)
Promotion of synaptic plasticity and long-term potentiation (LTP)
Neuroprotection against excitotoxicity and oxidative stress
Mimicry of NCAM function in neural signaling
Support for neuronal survival and differentiation

Dosage Protocol

Data compiled from the literature. This does not constitute medical advice.

Parameter	Value
Dose	5-10 mg per subcutaneous injection
Frequency	Once daily or every other day
Timing	Morning or per protocol
Duration	2-4 weeks

Reported Side Effects

Adverse effects described in the literature. Severity and frequency vary between individuals.

Injection site pain
Mild headache

Product Properties

Purity	>98%
Appearance	White lyophilized powder
Solubility	Soluble in water and bacteriostatic water
Source	Solid-phase peptide synthesis (SPPS)
Storage	Lyophilized: -20°C for up to 2 years, 2-8°C for up to 6 months. Reconstituted: 2-8°C for up to 4 weeks. Protect from light and moisture. Avoid repeated freeze-thaw cycles.