Cognitive & Neuroprotective

DSIP

Also known as: Peptídeo Indutor de Sono Delta

Molecular Identifiers

Molecular Formula

C35H48N10O15

PubChem CID

68816

Molecular Weight

848.8 Da

Overview

Neuropeptide that regulates sleep and circadian rhythms. Induces delta wave sleep (deep sleep) without forced sedative effect. Acts on neuroendocrine modulation and possesses adaptogenic and antioxidant properties.

Sequence (1 letter): WAGGDASGE
Extended notation: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu

Half-life

~15-25 minutes

Administration Route

Subcutaneous or intravenous

Category

Cognitive & Neuroprotective

Mechanism of Action

  • Induction of delta wave sleep (restorative deep sleep)
  • Modulation of circadian rhythms and the sleep-wake cycle
  • Neuroendocrine regulation (ACTH, cortisol, LH)
  • Antioxidant and anti-stress properties
  • Limitation of oxidative stress at the cellular level

Dosage Protocol

Data compiled from the literature. This does not constitute medical advice.

Parameter Value
Dose 100-300 mcg per subcutaneous injection
Frequency Once daily
Timing 30-60 minutes before bedtime
Duration 2-4 weeks

Reported Side Effects

Adverse effects described in the literature. Severity and frequency vary between individuals.

  • Daytime drowsiness
  • Mild morning headache
  • Dizziness

Presentations & Preparation

Vials of DSIP found in the research market:

5 mg10 mg15 mg20 mg

Reconstitution

  • Diluent: Bacteriostatic water
  • Volume: 2 ml per vial
  • Inject the diluent slowly against the vial wall
  • Gently swirl until fully dissolved
  • Never shake

Storage

  • Lyophilized: Refrigerated 2-8°C
  • Reconstituted: Refrigerated 2-8°C (up to 30 days)
  • Protect from direct light
  • Do not freeze after reconstitution
Reconstitution Calculator

Scientific Studies

Published studies on DSIP.

1987 · Eur Neurol

Effects of Delta-Sleep-Inducing Peptide on 24-Hour Sleep-Wake Behaviour in Severe Chronic Insomnia

Schneider-Helmert D
2021 · Molecules

Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke

Tukhovskaya EA, Ismailova AM, Shaykhutdinova ER, Slashcheva GA, Prudchenko IA, Mikhaleva II, Khokhlova ON, Murashev AN, Ivanov VT

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