Cognitive & Neuroprotective

Humanin

Also known as: HN, HNG (S14G-Humanin)

Molecular Identifiers

Molecular Formula

C119H204N34O32S2

CAS Number

330936-69-1

PubChem CID

16131438

Molecular Weight

2687 Da

Overview

Mitochondrial genome-derived peptide with 24 amino acids. Has potent neuroprotective and anti-apoptotic effects. Acts on insulin sensitization and protection against neurodegenerative diseases and metabolic stress.

Sequence (1 letter): MAPRGFSCLLLLTSEIDLPVKRRA

Extended notation: Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala

Half-life

~30 minutes

Administration Route

Subcutaneous

Mechanism of Action

Neuroprotection against beta-amyloid toxicity and oxidative stress
Anti-apoptotic effect via interaction with Bax and IGFBP-3
Insulin sensitization and metabolic improvement
Mitochondrial protection and maintenance of bioenergetic function
Reduction of systemic inflammation and endoplasmic reticulum stress

Dosage Protocol

Data compiled from the literature. This does not constitute medical advice.

Parameter	Value
Dose	1-5 mg per day subcutaneous (research)
Frequency	Once daily
Timing	Morning or per research protocol
Duration	4-12 weeks

Reported Side Effects

Adverse effects described in the literature. Severity and frequency vary between individuals.

Injection site pain (mild)
Headache (rare)

Product Properties

Purity	>95%
Appearance	White lyophilized powder
Solubility	Soluble in water and bacteriostatic water
Source	Solid-phase peptide synthesis (SPPS)
Storage	Lyophilized: -20°C for up to 2 years, 2-8°C for up to 6 months. Reconstituted: 2-8°C for up to 2 weeks. Protect from light and moisture. Avoid repeated freeze-thaw cycles.