Cognitive & Neuroprotective

P21

Also known as: P021

Overview

Peptide derived from CNTF (ciliary neurotrophic factor). Promotes BDNF upregulation and hippocampal neurogenesis. Inhibits tau protein phosphorylation, being researched in Alzheimer's and cognitive decline models.

Modified peptide — derived from CNTF with prenylated group, non-conventional sequence

Molecular Weight

773 Da

Half-life

~4-8 hours

Administration Route

Subcutaneous

Category

Cognitive & Neuroprotective

Mechanism of Action

  • BDNF upregulation (brain-derived neurotrophic factor)
  • Promotion of hippocampal neurogenesis
  • Inhibition of tau protein phosphorylation
  • Improvement of synaptic plasticity and memory
  • Neuroprotective action against neurodegeneration

Dosage Protocol

Data compiled from the literature. This does not constitute medical advice.

Parameter Value
Dose 5-10 mg per day via subcutaneous
Frequency Once daily
Timing Morning or early afternoon
Duration 4-12 weeks

Reported Side Effects

Adverse effects described in the literature. Severity and frequency vary between individuals.

  • Mild headache
  • Injection site pain

Presentations & Preparation

Vials of P21 found in the research market:

5 mg10 mg

Reconstitution

  • Diluent: Bacteriostatic water
  • Volume: 2 ml per vial
  • Inject the diluent slowly against the vial wall
  • Gently swirl until fully dissolved
  • Never shake

Storage

  • Lyophilized: Refrigerated 2-8°C
  • Reconstituted: Refrigerated 2-8°C (up to 30 days)
  • Protect from direct light
  • Do not freeze after reconstitution
Reconstitution Calculator

Scientific Studies

Published studies on P21.

2010 · FEBS Lett

Neurotrophic Peptides Incorporating Adamantane Improve Learning and Memory, Promote Neurogenesis and Synaptic Plasticity in Mice

Li B, Wanka L, Blanchard J, Liu F, Chohan MO, Iqbal K, Grundke-Iqbal I
2014 · Neurobiol Dis

Disease Modifying Effect of Chronic Oral Treatment with a Neurotrophic Peptidergic Compound in a Triple Transgenic Mouse Model of Alzheimer's Disease

Kazim SF, Blanchard J, Dai CL, Tung YC, LaFerla FM, Iqbal IG, Iqbal K

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