Pinealon
Also known as: Peptídeo cerebral
Molecular Identifiers
Overview
Cerebral bioregulatory tripeptide developed by the Khavinson group. Modulates gene expression in brain tissue, with neuroprotective properties and circadian rhythm support. Used in short, repeated cycles.
The main interest around Pinealon is neurological support — neuroprotection against oxidative stress, circadian rhythm modulation, and support for endogenous melatonin synthesis by the pineal gland. It is used in anti-aging contexts and for mild cognitive decline, cognitive function under stress, or age-related sleep disturbances.
It has no drug approval from the FDA, EMA, or ANVISA. It circulates through compounding pharmacies and bioregulatory medicine channels, in short cycles of 10-30 days repeated periodically, often combined with Epithalon in longitudinal protocols. It is also available in oral capsules in some formulations.
It belongs to the line of short tri- and tetrapeptides developed by the group of Russian researcher Vladimir Khavinson, derived from brain tissue extracts. The evidence base is predominantly Russian, with modern human clinical trials still limited.
Within the Khavinson family, Pinealon (the Glu-Asp-Arg tripeptide) sits in the pineal/cognitive subgroup with Epithalon and N-Acetyl-Epithalon: Epithalon is the classical pineal tetrapeptide focused on telomeres and anti-aging, N-Acetyl-Epithalon is its acetylated variant with proposed oral bioavailability, and Pinealon is presented more as a cerebral neuroprotector for short cyclic use. All of this comparative literature is largely Russian and preclinical.
EDR Glu-Asp-Arg Half-life
~2-4 hours
Administration Route
Subcutaneous or intramuscular
Category
Cognitive & Neuroprotective
Mechanism of Action
- Modulation of gene expression in brain tissues
- Neuroprotection against oxidative stress and neurotoxicity
- Support for circadian rhythm regulation
- Normalization of melatonin synthesis by the pineal gland
- Peptide bioregulatory effect on the central nervous system
Dosage Protocol
Data compiled from the literature. This does not constitute medical advice.
| Parameter | Value |
|---|---|
| Dose | 1-2 capsules orally (0.2 g per capsule, containing AKS-5 peptide complex) |
| Frequency | 1-2 times daily, with meals |
| Timing | With meals |
| Duration | 10-30 days per cycle, repeat the course every 4-6 months |
Reported Side Effects
Adverse effects described in the literature. Severity and frequency vary between individuals.
- Mild drowsiness
- Injection site pain (rare)
Product Properties
| Purity | >95% |
| Appearance | White lyophilized powder |
| Solubility | Soluble in water and bacteriostatic water |
| Source | Solid-phase peptide synthesis (SPPS) |
| Storage | Lyophilized: -20°C for up to 2 years, 2-8°C for up to 6 months. Reconstituted: 2-8°C for up to 4 weeks. Very stable tripeptide. Protect from light and moisture. |
Presentations & Preparation
Vials of Pinealon found in the research market:
Reconstitution
- Diluent: Bacteriostatic water
- Volume: 2 ml per vial
- Slowly inject the diluent against the vial wall
- Gently swirl until fully dissolved
- Never shake
- Also available in oral capsules
Storage
- Lyophilized: Refrigerated 2-8°C
- Reconstituted: Refrigerated 2-8°C (up to 30 days)
- Protect from direct light
- Do not freeze after reconstitution
Scientific Studies
Published studies on Pinealon.
EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer's Disease
Khavinson V, Linkova N, Kozhevnikova E, Trofimova S
Pinealon Increases Cell Viability by Suppression of Free Radical Levels and Activating Proliferative Processes
Khavinson V, Ribakova Y, Kulebiakin K, Vladychenskaya E, Kozina L, Arutjunyan A, Boldyrev A
Related Peptides
Adamax
100-500 mcg via intranasal or subcutaneous · 1-2 times daily
Cerebrolysin
5-30 ml per injection · Once daily
Cortagen
Dihexa
DSIP
100-300 mcg per subcutaneous injection · Once daily
Epithalon
1-5 mg per subcutaneous injection (some protocols use 5-10 mg per full cycle) · Once daily or every other day