Cognitive & Neuroprotective

Semax

Molecular Identifiers

Molecular Formula

C37H51N9O10S

PubChem CID

9811102

Overview

Nootropic peptide derived from ACTH (4-10) with a Pro-Gly-Pro addition. Improves focus and cognitive function. BDNF upregulation.

Sequence (1 letter): MEHFPGP
Extended notation: Met-Glu-His-Phe-Pro-Gly-Pro

Half-life

~3-5 minutes

Administration Route

Intranasal or subcutaneous

Category

Cognitive & Neuroprotective

Mechanism of Action

  • BDNF (brain-derived neurotrophic factor) upregulation
  • Dopamine and serotonin modulation
  • Neuroprotective effect
  • Improvement of synaptic plasticity
  • Anti-inflammatory action in the CNS

Dosage Protocol

Data compiled from the literature. This does not constitute medical advice.

Parameter Value
Dose 300-600 mcg per injection
Frequency 1-2 times daily
Timing Morning and/or afternoon
Duration 4-8 weeks

Reported Side Effects

Adverse effects described in the literature. Severity and frequency vary between individuals.

  • Mild nasal irritation (intranasal)
  • Headache (rare)

Presentations & Preparation

Vials of Semax found in the research market:

5 mg10 mg15 mg20 mg30 mg

Reconstitution

  • Diluent: Bacteriostatic water
  • Volume: 2 ml per vial
  • Slowly inject the diluent against the vial wall
  • Gently swirl until fully dissolved
  • Also available in nasal formulation

Storage

  • Lyophilized: Refrigerated 2-8°C
  • Reconstituted: Refrigerated 2-8°C (up to 30 days)
  • Protect from direct light
  • Do not freeze after reconstitution
Reconstitution Calculator

Scientific Studies

Published studies on Semax.

2005 · Zh Nevrol Psikhiatr Im S S Korsakova

Neuroprotective and nootropic drug Semax in the treatment of patients with cerebrovascular disease

Gusev EI, Skvortsova VI, Chukanova EI, et al.
2007 · Neurochem J

Semax, a synthetic analog of ACTH(4-10) with nootropic properties: a review

Ashmarin IP, Nezavibat'ko VN, Levitskaia NG, Koshelev VB, Kamensky AA

Related Peptides

Adamax

100-500 mcg via intranasal or subcutaneous · 1-2 times daily

Cerebrolysin

5-30 ml per injection · Once daily

Cortagen

5-10 mg per day via subcutaneous injection · Once daily

Dihexa

10-20 mg per subcutaneous injection or oral (research) · Once daily

DSIP

100-300 mcg per subcutaneous injection · Once daily

Epithalon

5-10 mg per injection · Once daily or every other day