Pal-GHK
Also known as: Palmitoyl Tripeptide-1, Palmitoil-GHK
Molecular Identifiers
Overview
Lipophilic form of the GHK tripeptide conjugated with palmitic acid for improved skin penetration. Stimulates collagen and elastin synthesis in the dermis, with repairing and anti-aging properties.
GHK Gly-His-Lys Half-life
Variable (topical use)
Administration Route
Topical
Category
Cosmetic & Skin
Mechanism of Action
- Stimulation of collagen synthesis via GHK signaling
- Palmitoyl group facilitates dermal penetration
- Promotion of extracellular matrix remodeling
- Antioxidant activity
- Regulation of genes associated with tissue repair
Dosage Protocol
Data compiled from the literature. This does not constitute medical advice.
| Parameter | Value |
|---|---|
| Dose | Topical application |
| Frequency | 1-2 times daily |
| Timing | Morning and/or evening |
| Duration | Continuous use |
Reported Side Effects
Adverse effects described in the literature. Severity and frequency vary between individuals.
- Mild skin irritation (rare)
Presentations & Preparation
Vials of Pal-GHK found in the research market:
Reconstitution
- Diluent: N/A (topical use)
- Volume: N/A
- Supplied as powder or solution
- Typical concentration 50-200 ppm in formulations
Storage
- Lyophilized: Room temperature
- Reconstituted: N/A
- Protect from light
- Keep in a dry place
Related Peptides
Acetyl Octapeptide-1
Topical 3-5% · Twice daily
AHK-Cu
Topical or 200-500 mcg subcutaneous · 1-2 times daily (topical), every other day (subcutaneous)
Argireline
Topical 5-10% or 100-250 mcg subcutaneous · Topical twice daily, subcutaneous 2-3x per week
Decapeptide-12
Topical application · 1-2 times daily
GHK Basic
Topical or 200-600 mcg subcutaneous · 1-2 times daily (topical), every other day (subcutaneous)
Matrixyl
Topical application · 1-2 times daily