Cognitive & Neuroprotective

Selank

Molecular Identifiers

Molecular Formula

C33H57N11O9

CAS Number

129954-34-3

PubChem CID

11765600

Molecular Weight

751.87 Da

Overview

Anxiolytic peptide derived from tuftsin with a Pro-Gly-Pro addition. Reduces anxiety without sedation. Immunomodulatory properties.

Sequence (1 letter): TKPRPGP
Extended notation: Thr-Lys-Pro-Arg-Pro-Gly-Pro

Half-life

~3-5 minutes

Administration Route

Intranasal or subcutaneous

Category

Cognitive & Neuroprotective

Mechanism of Action

  • GABAergic system modulation
  • Anxiolytic effect without sedation
  • Immune modulation (IL-6, interferons)
  • Stabilization of endogenous enkephalins
  • Neuroprotective effect

Dosage Protocol

Data compiled from the literature. This does not constitute medical advice.

Parameter Value
Dose 250-500 mcg per injection
Frequency 1-2 times daily
Timing Morning and/or afternoon
Duration 4-8 weeks

Reported Side Effects

Adverse effects described in the literature. Severity and frequency vary between individuals.

  • Mild fatigue
  • Nasal irritation (intranasal)
  • Headache (rare)

Product Properties

Purity >98%
Appearance White lyophilized powder
Solubility Soluble in water, bacteriostatic water, and saline. Suitable for intranasal formulation.
Source Solid-phase peptide synthesis (SPPS)
Storage Lyophilized: -20°C for up to 2 years, 2-8°C for up to 6 months. Reconstituted: 2-8°C for up to 4 weeks. Protect from light and moisture. Avoid repeated freeze-thaw cycles.

Presentations & Preparation

Vials of Selank found in the research market:

5 mg10 mg15 mg20 mg

Reconstitution

  • Diluent: Bacteriostatic water
  • Volume: 2 ml per vial
  • Slowly inject the diluent against the vial wall
  • Gently swirl until fully dissolved
  • Also available in nasal formulation

Storage

  • Lyophilized: Refrigerated 2-8°C
  • Reconstituted: Refrigerated 2-8°C (up to 30 days)
  • Protect from direct light
  • Do not freeze after reconstitution
Reconstitution Calculator

Scientific Studies

Published studies on Selank.

2008 · Neurochem J

Selank: an anxiolytic peptide

Uchakina ON, Uchakin PN, Miasoedov NF, et al.

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