Tripeptide-29
Also known as: Collagen Tripeptide, GHK Mimic
Molecular Identifiers
Overview
Synthetic tripeptide that mimics collagen fragments, stimulating type I collagen production in the dermis. Sequence based on repetitive motifs of the collagen alpha chain.
GPO Collagen motif-based tripeptide. Structure varies between manufacturers.
Half-life
Variable (topical use)
Administration Route
Topical
Category
Cosmetic & Skin
Mechanism of Action
- Stimulation of type I collagen synthesis
- Signaling to dermal fibroblasts
- Improvement of skin elasticity
- Strengthening of the dermal barrier
Dosage Protocol
Data compiled from the literature. This does not constitute medical advice.
| Parameter | Value |
|---|---|
| Dose | Topical application |
| Frequency | 1-2 times daily |
| Timing | Morning and/or evening |
| Duration | Continuous use |
Reported Side Effects
Adverse effects described in the literature. Severity and frequency vary between individuals.
- Mild skin irritation (very rare)
Product Properties
| Purity | >98% |
| Appearance | White lyophilized powder |
| Solubility | Soluble in water and bacteriostatic water |
| Source | Solid-phase peptide synthesis (SPPS) |
| Storage | Lyophilized: -20°C for up to 2 years, 2-8°C for up to 6 months. Reconstituted: 2-8°C for up to 4 weeks. Protect from light and moisture. Avoid repeated freeze-thaw cycles. |
Presentations & Preparation
Vials of Tripeptide-29 found in the research market:
Reconstitution
- Diluent: N/A (topical use)
- Volume: N/A
- Supplied as powder or incorporated into formulations
- Typical concentration 50-200 ppm
Storage
- Lyophilized: Room temperature
- Reconstituted: N/A
- Protect from light
- Store in a cool, dry place
Related Peptides
Acetyl Octapeptide-1
Topical 3-5% · Twice daily
AHK-Cu
Topical or 200-500 mcg subcutaneous · 1-2 times daily (topical), every other day (subcutaneous)
Argireline
Topical 5-10% or 100-250 mcg subcutaneous · Topical twice daily, subcutaneous 2-3x per week
Decapeptide-12
Topical application · 1-2 times daily
GHK Basic
Topical or 200-600 mcg subcutaneous · 1-2 times daily (topical), every other day (subcutaneous)
Matrixyl
Topical application · 1-2 times daily